Невідома безумовна нижня межа для жодного k ≥ 2k≥2 в моделі багатошарової ТМ (або будь-якої моделі, сильнішої за неї).
NTIME(nk)≠TIME(nk)c≥1kNTIME(nk)⊈TIME−SPACE(nk,nk/c)NTIME(nk)⊈TIME−SPACE(nk,nk/c). Here, TIME−SPACE(nk,nk/c)TIME−SPACE(nk,nk/c) is the class of languages recognized by machines using time nknk and space nk/cnk/c simultaneously. Clearly TIME−SPACE(nk,nk/c)⊆TIME(nk)TIME−SPACE(nk,nk/c)⊆TIME(nk) but it is not known whether they are equal.
If you assume for some k≥2k≥2 that NTIME(nk)=TIME(nk)NTIME(nk)=TIME(nk), you get interesting consequences. P=NPP=NP is obvious, but it also implies that NL≠PNL≠P. This can be proved using an "alternation-trading" argument. Basically, for every kk and every language L∈NLL∈NL, there is a constant cc and some alternating machine that recognizes LL and makes cc alternations, guesses O(n)O(n) bits per alternation, then switches to a deterministic mode and runs in nknk time. (This follows, for example, from playing around with the constructions in Fortnow, "Time-Space Tradeoffs for Satisfiability" (1997).) Now if TIME(nk)=NTIME(nk)TIME(nk)=NTIME(nk) then all these cc alternations can be removed with only a small amount of overhead, and you end up with a TIME(nk)TIME(nk) computation that recognizes LL. Hence NL⊆TIME(nk)≠PNL⊆TIME(nk)≠P. Probably no such alternating simulation exists, but if you can rule it out, then you'll have the lower bound you seek. (Note: I believe that the above argument is also in Kannan's paper.)